Orthostatic Hypotension in Middle-Age and Risk of Falls

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Orthostatic hypotension and cardiovascular risk.

Orthostatic hypotension (OH) results from a failure of neural and circulatory mechanisms to compensate for the reduction in venous return that normally occurs on assuming the upright posture. OH is defined as a fall in systolic blood pressure of 20 mm Hg or diastolic blood pressure of 10 mm Hg measured within 3 minutes of standing.1 OH can result from side effects of medications, intravascular ...

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Orthostatic Hypotension and Risk of Incident Dementia

In clinical practice, orthostatic hypotension (OH), a blood pressure drop in standing position, is a common condition affecting at least 6% of the population. OH has been consistently associated with increased mortality and risk of cardiovascular events. This leads us to question whether cerebral perfusion variations induced by OH could contribute to an increased risk of dementia. An increase i...

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Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study.

BACKGROUND An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations. METHODS AND RESULTS We investigated the association between OH (a decrease of 20 mm Hg in systolic blood pressure or a decrease of 10 mm Hg in diastolic blood pressure on standing) and 13-year mortality among middle-aged black and wh...

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Orthostatic hypotension.

A 29-year-old white woman (weight, 1211b; height, 5 ft 6 in.) was referred to the Hypertension Unit of Massachusetts General Hospital in December 1984. She had been athletic and apparently in excellent health until September 1979 when she contracted an upper respiratory tract infection associated with wheezing. She was treated with prednisone for 5 days with resolution of the symptoms but later...

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OBJECTIVES Droxidopa is a prodrug of norepinephrine indicated for the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black out" in adult patients with symptomatic neurogenic orthostatic hypotension caused by primary autonomic failure including Parkinson disease (PD). The objective of this study was to compare fall rates in PD patients with symptomatic...

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ژورنال

عنوان ژورنال: American Journal of Hypertension

سال: 2016

ISSN: 0895-7061,1941-7225

DOI: 10.1093/ajh/hpw108